Crystal structure of SRC kinase domain with covalent inhibitor RL3

Crystal structure of SRC kinase domain with covalent inhibitor RL3 Descriptor: (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide, Proto-oncogene tyrosine-protein kinase Src Authors: Michalczyk, A, Rode, H.B, Gruetter, C, Rauh, D. Deposit date: 2007-07-13 Release date: 2008-03-11 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg.Med.Chem., 16, 2008结合共价抑制剂RL3的SRC激酶结构域晶体结构 描述符：(2E)-N-{4-[(3-溴苯基)氨基]喹唑啉-6-基}-4-(二甲氨基)丁-2-烯酰胺、原癌基因酪氨酸蛋白激酶Src（Proto-oncogene tyrosine-protein kinase Src） 作者：Michalczyk, A、Rode, H.B、Gruetter, C、Rauh, D. 沉积日期：2007-07-13 发布日期：2008-03-11 最后修改日期：2024-11-13 实验方法：X射线衍射（2.33 Å） 引用文献：《不可逆抑制剂克服EGFR耐药性的结构机制研究》，Bioorg.Med.Chem.，16，2008