The Mexican dataset of an rTMS clinical trial on cocaine use disorder patients: SUDMEX TMS

The SUDMEX_TMS dataset is the result of a longitudinal clinical trial of cocaine use disorder patients that were treated with rTMS at 5-Hz on the left dorsolateral prefrontal cortex (lDLPFC) for a 2 week double-blind acute phase and an open-label maintenance phase that included clinical, cognitive and MRI data acquisition. The design was a double-blind placebo-controlled randomized controlled trial with parallel groups (acute phase). The study was done at the National Institute of Psychiatry . Each patient had more than one clinical and MRI session or time point from baseline (T0), 2 weeks (T1), 3 months (T2), 6 months (T3) and some patients had 12 months (T4). The T14 time point was only for patients in the Sham group who decided to continue the clinical trial with open-label rTMS. The T14 refers to 2 weeks after T1 (4 weeks after T0). The MRI sequences were: 1) T1-weighted, 2) rsfMRI 10 min, 3) HARDI-DWI multishell (next release). The data set is curated and organized by test and item for each experimental phase and also has a dictionary to define the variables measured. If you require more information about data or scales, please contact us. LANIREM (National MRI Laboratory), Institute of Neurobiology, Universidad Nacional Autónoma de México (UNAM), Querétaro, México. Diego Angeles Valdez, M. Sc. [e-mail] [e-mail] Eduardo A. Garza-Villarreal, M.D., Ph.D. [e-mail] [e-mail]_TMS数据集是一项针对可卡因使用障碍患者的纵向临床试验成果，所有受试者均接受了针对左侧背外侧前额叶皮层（left dorsolateral prefrontal cortex, lDLPFC）的5Hz重复经颅磁刺激（repetitive transcranial magnetic stimulation, rTMS）治疗。试验分为2周双盲急性期与开放标签维持阶段，期间同步采集临床评估、认知测试与磁共振成像（magnetic resonance imaging, MRI）数据。该试验急性期阶段采用平行组设计的双盲安慰剂对照随机对照试验，由墨西哥国立精神病学研究所开展。所有受试者均在基线（T0）、2周（T1）、3个月（T2）、6个月（T3）设置了至少1次临床与MRI随访节点，部分受试者额外完成了12个月（T4）的随访。T14节点仅针对选择继续接受开放标签rTMS治疗的假手术组受试者，其定义为T1术后2周（即基线后4周）。本次试验采集的MRI序列包括：1）T1加权成像；2）10分钟静息态功能磁共振成像（resting-state functional MRI, rsfMRI）；3）多壳层HARDI-DWI成像（将在下一版本发布）。本数据集已按照试验阶段、检测项目进行整理与标注，并附带变量定义字典以供查阅。若需获取更多数据或量表相关信息，请联系以下机构与人员：墨西哥国立自治大学（Universidad Nacional Autónoma de México, UNAM）神经生物学研究所国家MRI实验室（LANIREM），克雷塔罗，墨西哥。Diego Angeles Valdez，理学硕士，电子邮箱：[e-mail]、[e-mail]。Eduardo A. Garza-Villarreal，医学博士、哲学博士，电子邮箱：[e-mail]、[e-mail]。