Treatment of bowel dysfunction after surgery for rectal cancer using transanal irrigation or laxatives

Primary objectives: TAI is used as a second-line treatment following unsuccessful personalised conservative treatment (PCT) of LARS. However, it is unknown if scheduled, initiated defecation with the aid of a glycerol suppository will have the same clinical effect as TAI. Thus, the aim of this study is to compare the effect of TAI with a glycerol suppository in patients suffering from major LARS. Primary endpoints: The primary endpoint will be the improvement of the main symptom using the Measure My Medical Outcome Profile (MYMOP) score comparing the TAI group to the glycerol suppository group.