Dataset related to: "In-Patient Trajectories and Effects of Training in Survivors of COVID-19-Associated Acute Respiratory Failure"

We provide the raw data used for the following article: Vitacca M, Paneroni M, Salvi B, Comini L, Ambrosino N. In-Patient Trajectories and Effects of Training in Survivors of COVID-19-Associated Acute Respiratory Failure. Respir Care. 2022 Jun;67(6):657-666. doi: 10.4187/respcare.09808. Abstract Background: Pulmonary rehabilitation (PR) is useful in survivors of COVID-19-associated acute respiratory failure (ARF). The aim of this retrospective study on in-patient PR was to report rehabilitative trajectories and effects of cycle training. Methods: According to the Short Physical Performance Battery (SPPB) score at admission (T0), participants were allocated to stage 1 (SPPB < 6), stage 2 (SPPB ≥ 6 and < 10), or stage 3 (SPPB ≥ 10) and performed increasing level of activities from passive exercises to free walking, balance exercises, strength exercises, and tailored cycle-ergometer endurance training. The primary outcome was SPPB. 6-min walk distance (6MWD), Medical Research Council score, Barthel dyspnea index, and rate of subjects able to cycling were also assessed. Results: Data of 123 participants were analyzed. At T0, 44 (35.8%), 50 (40.6%), and 29 (23.6%) participants were allocated to stages 1-3, respectively. At discharge, participants showed significant improvements in SPPB, independent of the initial stage, 81 (65.8%) improving more than its minimal clinically important difference. At T1, the proportion of participants in stages 1 and 2 decreased, whereas significantly increased in stage 3 (P = .003), (being 9.8%, 33.3%, and 56.9% for stages 1-3, respectively; P <.001). Sixty-nine of 123 participants (56.1%) underwent cycle exercise training. In participants able to perform it, 6MWD improved by 115 (65-240) m and 60 (40-118) m in participants with and without exercise-induced desaturation, respectively, with significant difference between groups (P = .044). Conclusions: In-patient PR could be tailored and progressively increased to survivors of COVID-19-associated ARF; cycle training was feasible in half of the participants. Benefits were independent of initial stage of physical performance and allowed participants to move from lower to higher levels of activities.我们提供了用于下述研究论文的原始数据集： Vitacca M, Paneroni M, Salvi B, Comini L, Ambrosino N. 新型冠状病毒肺炎相关性急性呼吸衰竭幸存者的住院康复轨迹与训练效果. 《呼吸治疗》（Respir Care）. 2022年6月;67(6):657-666. DOI: 10.4187/respcare.09808. 摘要 背景：肺康复（pulmonary rehabilitation, PR）对新型冠状病毒肺炎相关性急性呼吸衰竭（acute respiratory failure, ARF）幸存者具有临床价值。本项针对住院肺康复的回顾性研究，旨在阐明康复轨迹与功率自行车耐力训练的效果。 方法：根据入院时（T0）的简易体能状况量表（Short Physical Performance Battery, SPPB）评分，受试者被分为1级（SPPB评分<6）、2级（SPPB评分≥6且<10）及3级（SPPB评分≥10），并完成从被动训练、自由步行、平衡训练、力量训练到个性化功率自行车耐力训练的渐进式活动方案。本研究的主要结局指标为SPPB评分；同时评估了6分钟步行距离（6-min walk distance, 6MWD）、医学研究理事会评分、巴氏呼吸困难指数以及能够完成骑行训练的受试者比例。 结果：共纳入123名受试者进行数据分析。入院时（T0），分别有44名（35.8%）、50名（40.6%）及29名（23.6%）受试者被分配至1~3级。出院时，无论初始体能分级如何，受试者的SPPB评分均出现显著改善，其中81名（65.8%）受试者的改善幅度超过最小临床重要差值。在出院后随访点（T1），1级和2级受试者的占比下降，而3级受试者占比显著升高（P=0.003）；此时1~3级受试者占比分别为9.8%、33.3%及56.9%（P<0.001）。123名受试者中共有69名（56.1%）完成了功率自行车训练。在能够完成训练的受试者中，合并运动诱发性血氧饱和度下降者的6MWD提升了115（65~240）米，未合并者提升了60（40~118）米，两组间差异具有统计学意义（P=0.044）。 结论：针对新型冠状病毒肺炎相关性急性呼吸衰竭幸存者，可开展个性化且渐进式的住院肺康复方案；半数受试者可完成功率自行车训练。康复获益与初始体能状态分级无关，且可帮助受试者从低活动水平进阶至更高活动水平。