BIOGRID CURATED DATA FOR DDC1 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for DDC1 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress

DDC1（酿酒酵母S288c）蛋白质-蛋白质、遗传和化学相互作用数据集，由BioGRID（https://thebiogrid.org）精心整理；定义：DNA损伤检查点蛋白；PCNA样复合体的一部分，对于DNA损伤反应至关重要，在抑制细胞周期以应对未修复的重组中间体时，起到pachytene检查点的功能；具有潜在Cdc28p底物活性；在DNA复制压力下形成核聚集体。