EDEN2020 Human Brain MRI Datasets for Brain Glioma Patients

The datasets available in this folder regard the acquisition of high-resolution MRI images of a cohort of 30 brain glioma adult patients acquired on a 3 Tesla Philips scanner at the Neuroradiology Unit and CERMAC <em>(Center of Excellence for High Field Magnetic Resonance)</em>, Vita-Salute San Raffaele University and IRCCS Ospedale San Raffaele, Milano, Italy. The acquisition is carried out in the context of the EU’s Horizon EDEN2020 project as part of the work for <em>Deliverable D2.2 Human Brain Imaging Database</em>. Histopathological and molecular details of this cohort of patients are reported in the Patients' Table included in the <em>Readme.md</em> file. The data includes: 3D_FLAIR_Tra: Fluid‑Attenuated Inversion Recovery volumetric sequence acquired on the axial plane for morphological characterization of the lesion. raw_data_DTI_32: Diffusion Tensor Imaging raw data. This is a diffusion-weighted Spin Echo EPI single-shot pulse sequence acquired on the axial plane along 32 gradient directions at a b-value of 1000 s/mm² and one volume without diffusion-weighting (b0 image). Axial (AD), Radial (RD), Mean Diffusivity (MD) and Fractional Anisotropy maps derived from 'raw_data_DTI_32' sequence using the Philips IntelliSpace Portal software platform, version 8.0 (Philips Healthcare, Best, The Netherlands) and saved using the ‘_map_DTI_32_gray' suffix. raw_data_NODDI: multi-compartmental dMRI sequence for advanced tractography and NODDI analyses, including an axial high angular resolution diffusion-weighted imaging (HARDI) acquisition along 60 gradient directions at a b-value of 3000 s/mm²a DTI acquisition along 35 directions at a b-value of 711 s/mm² and 11 volumes without diffusion-weighting (b0 images). Phase-encoding direction was anterior-to-posterior for all these acquisitions. B0_reverse: a sequence without diffusion-weighting having the same geometrical parameters of the ‘raw_data_NODDI’ images,but acquired using a reversed phase-encoding direction (posterior-to-anterior). This volume allowed estimation and correction for susceptibility-induced distortions. SWI_axial: Susceptibility‑Weighted Imaging sequence acquired on the axial plane for detection of Intratumoral Susceptibility Signals (ITSS), microhemorrages and calcifications. Phase map and magnitude image are separated in two distinguished files, using the ‘_ph’ suffix for phase maps. s3DI_MC_HR: three-dimensional high-resolution time of flight (TOF) MR angiography acquisition to visualize flow within the arterial vessel. Post-gadolinium T1_3D_PROSET_Sag: T1-weighted volumetric sequence acquired on the sagittal plane for morphological characterization of the lesions and detection of areas of contrast enhancement. Note that all MRI data files were converted from DICOM series using Chris Rorden's dcm2niiX version v1.0.20200331.本文件夹内的数据集，收录了意大利米兰维塔-萨尔瓦多圣拉斐尔大学及IRCCS圣拉斐尔医院神经放射科与CERMAC（高场磁共振卓越中心，Center of Excellence for High Field Magnetic Resonance）团队使用3T飞利浦扫描仪采集的30例成人脑胶质瘤患者队列的高分辨率磁共振成像（MRI）数据。该采集工作隶属于欧盟Horizon EDEN2020项目，作为交付文档D2.2《人类脑成像数据库》（Deliverable D2.2 Human Brain Imaging Database）的组成部分。 本队列患者的组织病理学与分子生物学细节，收录于"Readme.md"文件中的患者表格内。本次公开的数据包含以下内容： 1. 3D_FLAIR_Tra：轴位采集的液体衰减反转恢复（Fluid-Attenuated Inversion Recovery, FLAIR）三维容积序列，用于病灶的形态学表征。 2. raw_data_DTI_32：弥散张量成像（Diffusion Tensor Imaging, DTI）原始数据。该序列为沿轴位采集的单次激发自旋回波平面成像（Spin Echo EPI）弥散加权脉冲序列，沿32个梯度方向采集，b值为1000 s/mm²，同时包含1幅无弥散加权的对照图像（b0图像）。使用飞利浦IntelliSpace Portal 8.0版本软件平台（荷兰飞利浦医疗，贝斯特市），从raw_data_DTI_32序列中衍生得到轴向弥散系数（Axial Diffusivity, AD）、径向弥散系数（Radial Diffusivity, RD）、平均弥散系数（Mean Diffusivity, MD）及各向异性分数（Fractional Anisotropy, FA）图，并以"_map_DTI_32_gray"作为后缀保存。 3. raw_data_NODDI：用于先进纤维束追踪与NODDI分析的多室扩散磁共振成像（dMRI）序列，包含：沿60个梯度方向采集、b值为3000 s/mm²的轴向高角分辨率弥散成像（High Angular Resolution Diffusion Imaging, HARDI）；沿35个梯度方向采集、b值为711 s/mm²的DTI序列；以及11幅无弥散加权的对照图像（b0图像）。所有上述采集的相位编码方向均为前→后。 4. B0_reverse：无弥散加权序列，几何参数与raw_data_NODDI图像一致，但相位编码方向为后→前，用于估算并校正磁化率诱导的图像畸变。 5. SWI_axial：轴位采集的磁敏感加权成像（Susceptibility-Weighted Imaging, SWI）序列，用于检测瘤内磁敏感信号（Intratumoral Susceptibility Signals, ITSS）、微出血及钙化。相位图与幅值图像分别保存为两个独立文件，相位图以"_ph"作为后缀标识。 6. s3DI_MC_HR：三维高分辨率时间飞跃（Time of Flight, TOF）磁共振血管造影序列，用于可视化动脉内血流情况。 7. Post-gadolinium T1_3D_PROSET_Sag：矢状位采集的T1加权三维容积序列，用于病灶的形态学表征及对比强化区域的检测。 所有MRI数据文件均由Chris Rorden开发的dcm2niiX v1.0.20200331版本从DICOM序列转换而来。