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A New Strategy for Efficient Synthesis of Medium and Large Ring Lactones without High Dilution or Slow Addition

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NIAID Data Ecosystem2026-03-07 收录
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https://figshare.com/articles/dataset/A_New_Strategy_for_Efficient_Synthesis_of_Medium_and_Large_Ring_Lactones_without_High_Dilution_or_Slow_Addition/2430760
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We have developed an efficient method for medium and large ring lactone synthesis by a conceptually different ring-expansion strategy. The design of an unprecedented ring conjunction mode of oxetene, combined with the appropriate choice of a Lewis acid promoter and an additive, constitutes the key components of the new process. Enabled by this new approach, the reaction does not require high dilution or slow addition.
创建时间:
2016-02-19
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