FoldamerDB
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Foldamers are non-natural oligomers that mimic the structural behaviour of natural peptides, proteins and nucleotides by folding into a well-defined 3D conformation in solution. Since their first description about two decades ago, numerous studies have been undertaken dealing with the design, synthesis, characterization and application of foldamers. They have huge application potential as antimicrobial, anticancer and anti-HIV agents and in materials science. Despite their importance, there is no publicly available web resource providing comprehensive information on these compounds. Here we describe FoldamerDB, an open-source, fully annotated and manually curated database of peptidic foldamers. FoldamerDB holds the information about the sequence, structure and biological activities of the foldamer entries. It contains the information on over 1319 species and 1018 activities, collected from more than 160 research papers. The web-interface is designed to be clutter-free, user-friendly and it is compatible with devices of different screen sizes. The interface allows the user to search the database, browse and filter the foldamers using multiple criteria. It also offers a detailed help page to assist new users. FoldamerDB is hoped to bridge the gap in the freely available web-based resources on foldamers and will be of interest to diverse groups of scientists from chemists to biologists. The database can be accessed at http://foldamerdb.ttk.hu/.
折叠体（Foldamers）是一类非天然寡聚物，可通过在溶液中折叠形成明确界定的三维构象，模拟天然肽、蛋白质与核苷酸的结构行为。自二十年前首次被报道以来，围绕折叠体的设计、合成、表征与应用已开展大量研究。折叠体作为抗菌、抗癌及抗HIV药剂，以及在材料科学领域均具备巨大应用潜力。尽管折叠体具有重要研究价值，但目前尚无公开网络资源可提供这类化合物的全面信息。本研究介绍FoldamerDB——一款开源、全注释且经人工精编的肽类折叠体数据库。该数据库存储了所有折叠体条目的序列、结构及生物活性信息，从160余篇研究论文中收集了1319种折叠体及1018项生物活性数据。该数据库的网页界面设计简洁清爽、易用性强，且适配各类屏幕尺寸的设备；用户可通过该界面检索数据库，并基于多维度筛选条件浏览与筛选折叠体条目。此外，数据库还设有详细的帮助页面，可帮助新用户快速熟悉平台操作。本数据库旨在填补折叠体领域现有免费网络资源的空白，将受到从化学家到生物学家等多领域科研人员的关注与青睐。用户可通过网址http://foldamerdb.ttk.hu/访问该数据库。
