Compounds excreted by Caenorhabditis elegans at 4°C alleviate gamma-radiation injury through the gcy-5-mediated lysosomal pathway

In this work, C. elegans was found to withstand high-dose radiation when exposed to 4°C for 4 hours before irradiation. After experimental confirmation, it was found that compounds excreted by C. elegans at 4°C inhibited radiation injury. The excreted compounds targeted the lysosomal pathway mediated by guanylyl cyclase gcy-5. Furthermore, activation of gcy-5 by the excreted compounds inhibited the expression of fat-5, which suppresses the lysosomal pathway.

本研究发现，秀丽隐杆线虫（C. elegans）在接受辐照前于4℃环境预处理4小时，便可耐受高剂量辐射。经实验验证，该线虫在4℃下分泌的化合物可抑制辐射损伤。上述分泌化合物靶向由鸟苷酸环化酶gcy-5介导的溶酶体通路。进一步研究表明，分泌化合物对gcy-5的激活可抑制fat-5的表达，而fat-5本身可抑制溶酶体通路。