TLR3 overexpression induces invasion of prostate cancer cells, whereas its activation triggers apoptosis

Toll-like receptors are proteins that play an important role in the innate immune system. They are frequently detected in immune cells such as macrophages or dendritic cells. Their role has been in part studied in prostate cancer. However, in the present study we focus mostly on their functional significance at various types of cancer therapy resistance. Examination of differential gene expression analysis between control DU145 cells (clones A6, D7) and cells overexpressing TLR3 (clones B9, C12)