The HLA system of donors and recipient is routinly sequenced in the EFS of Grenoble (FRANCE) using NGS method (MiSeq, Illumina), and some new alleles are discovered and declared.
The highly polymorphic human major histocompatibility complex (MHC) also known as the human leukocyte antigen (HLA) encodes class I and II genes that are the cornerstone of the adaptive immune system.