Maintaining Blood Pressure Would be Effective Treatment against Dementia in Elderly

Hypertension is a significant public health apprehension. The commonness keeps rising, and it is a risk issue for a number of unfavorable health outcomes counting a refuse in cognitive utility. The commonness of hypertension and age-related dementia is increasing in Asian countries, within the aged grouping. This review aims to talk about potential treatments for high blood pressure in the aged and suggest a most favorable objective for BP relation to cognitive results. Our review discusses a number of studies on associated blood pressure treatments to stay contentious and the penalty if the action aim is also low or violent. Longitudinal and cross-sectional, studies were incorporated in this appraisal. A most favorable systolic blood pressure of 120-130 mm Hg is not compulsory, particularly in no diabetic hypertensive patients with significant risk factors. The renin-angiotensin scheme (RAS) is extremely occupied in not only hypertension other than also lifestyle-related diseases, and might contribute to the pathological mechanism in dementia; consequently, RAS instruction is anticipated to stop dementia.

高血压是一项重大的公共卫生关切议题。其患病率持续攀升，且是多种不良健康结局的风险因素，包括认知功能下降。在亚洲国家的老年人群体中，高血压与年龄相关性痴呆的患病率均呈上升趋势。本综述旨在探讨老年人群高血压的潜在治疗方案，并提出与认知结局相关的最佳血压（blood pressure, BP）控制目标。本综述探讨了多项相关血压治疗研究的争议焦点，以及血压控制目标过低或过高所带来的不良后果。本次综述纳入了纵向研究与横断面研究。收缩压的最佳控制目标并非固定为120~130 mmHg，尤其对于合并多重危险因素的非糖尿病高血压患者而言。肾素-血管紧张素系统（renin-angiotensin system, RAS）不仅广泛参与高血压的发生发展，还与生活方式相关性疾病密切相关，且可能参与痴呆的病理生理过程；因此，靶向调控RAS有望预防痴呆的发生。