Single-cell transcriptomes combining with consecutive genomics reveal clonal evolution and gene regulatory networks in relapsed and refractory multiple myeloma

In the end-stage of MM (PD9), malignant PCs appeared in the patient's peripheral blood (PB), the proportion of which reached 10%. Her PB mononuclear cells (PBMC) were used for scRNA-seq. One PBMC sample from a RRMM patient.