CYP26A1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

本基因编码了细胞色素P450超家族酶的一个成员。细胞色素P450蛋白是一类单加氧酶，催化了许多参与药物代谢和胆固醇、类固醇及其他脂质合成的反应。该内质网蛋白作用于视黄醇类物质，包括全反式视黄酸（RA），并具备4-羟基化和18-羟基化活性。此酶调节细胞内视黄酸的水平，该水平与胚胎及成年组织中基因表达的调控密切相关。目前已报道该基因存在两种不同的剪接转录变体，它们编码了不同的同型异构体。[由RefSeq提供，2008年7月]