FSTL3 promotes colorectal cancer by activating the HIF1 pathway

NIAID Data Ecosystem2026-05-02 收录

结直肠癌分子机制

FSTL3-HIF1通路

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1146563 数据链接链接失效反馈

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This study highlights FSTL3's significance in CRC, linked to adverse outcomes and invasiveness, suggesting the HIF1 pathway mediates FSTL3's oncogenic functions, offering insights for targeting FSTL3 in CRC treatment.

创建时间：

2024-08-10

Additional file 3 of SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner

结直肠癌分子机制

m6ARNA修饰

Additional file 3: Table S3. Target mRNAs of the SRSF9 protein in POSTAR2.

Figshare2024-02-16 更新80

Next Generation Sequencing Facilitates Quantitative Analysis of Transcriptomes in negative control and miR-1290 knockdown HCT116 cells

结直肠癌分子机制

MicroRNA功能研究

Colorectal cancer (CRC) ranks third in incidence and second in mortality among cancers worldwide. Emerging researches showed that microRNAs (miRNAs) play an important role in CRC progression. Here, we

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FLANC, a novel primate-specific long non-coding RNA, is involved in colorectal carcinogenesis and holds potential as a novel therapeutic target (shRNA). FLANC, a novel primate-specific long non-coding RNA, is involved in colorectal carcinogenesis and holds potential as a novel therapeutic target (shRNA)

结直肠癌分子机制

非编码RNA靶点

FLANC is significantly up-regulated in two cohorts of CRC samples and high level of FLANC is associated with poor patient survival in two additional independent cohorts. FLANC influences cellular grow

NIAID Data Ecosystem30

Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes [HCT116]

炎症调控

结直肠癌分子机制

Chronic inflammation is epidemiologically linked to the pathogenesis of gastrointestinal diseases, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). However, our understanding of

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An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer [rnaseq_ls180]. An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer [rnaseq_ls180]

结直肠癌分子机制

RNA-seq转录组学

Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant prope

NIAID Data Ecosystem30

FSTL3 promotes colorectal cancer by activating the HIF1 pathway

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