Expression of IDO1-2, iNOS and interferon-inducible GTPases in Chlamydia muridarum infected BALB/c mouse lung tissues

We wanted to screen the expression of known and putative antichlamydial genes in vivo. As an open approach, we performed RNA sequencing of Chlamydia muriadrum infected mouse lung tissues. RNA seq revealed that a diverse set of antichlamydial genes were induced by the infection, including previously described unique human and murine genes. We further characterized the source and activity of indolamine 2,3-dioxygenase genes, previously described as key human effectors. Comparison of Chlamydia muridarum infected and uninfected BALB/c mouse lung tissues