Inhibition of ?-glutamyl transpeptidase suppresses LPS induced asthma exacerbation in a mouse model

To investigate the role of ?-glutamyltranspeptidase in severe asthma, we established an OVA/ LPS-induced asthma model. Inflammation analysis and second-generation sequencing revealed the mechanism by which inhibition of ?-glutamyltranspeptidase inhibited LPS-induced asthma exacerbation in mice. Overall design: In order to study the effect of GGsTop on asthma, we set up control group (PBS), asthma group (OL), and experimental group (OLG), and isolated trachea for transcriptomic sequencing. Gene expression profiling was performed on RNA-seq data.