Multi-modal characterization of rodent dental development

The developing dentition comprises vital hard tissues of the craniofacial complex that undergo complex and distinct mineralization stages of development through changes in their physicochemical properties. This study investigates the mechanical and chemical properties of the developing enamel, dentin, and bone in mouse mandibles. We employ a multi-modal, multi-scale analysis of the developing post-natal incisor and first molar by integrating micro-computed tomography, nanoindentation, energy dispersive spectroscopy, and Raman spectroscopy. Our findings reveal patterns of mechanical, elemental, and chemical changes across the developing incisor in enamel and dentin. Magnesium, iron, and the carbon-to-phosphate ratio were significantly associated with enamel properties, while magnesium composition was associated with dentin. These results demonstrate that the mineral composition drives mechanical properties across these developing craniofacial hard tissues. The integrative multi-modal app..., , # Multimodal characterization of rodent dental development

Dataset DOI: [10.1021/acsami.5c08408](https://doi.org/10.1021/acsami.5c08408 \"DOI URL\")

## Description of the data and file structure

The data presented in this study were collected as part of a multi-modal investigation into the development of mineralized dental tissues in the postnatal mouse mandible. We employed a combination of high-resolution imaging (micro-computed tomography), mechanical testing (nanoindentation), elemental analysis (energy dispersive X-ray spectroscopy), and chemical profiling (Raman spectroscopy) to characterize the physicochemical changes in enamel, dentin, and alveolar bone during tooth development. These efforts aimed to elucidate how variations in mineral composition contribute to the evolving mechanical properties of the developing mouse tooth.

### Files and variables

#### File: F1A.tiff

Description: Three-dimensional microcomputed tomography (micro CT) reconstruction of the maxillary and ma...,

发育中的牙列属于颅面复合体的重要硬组织，其理化性质会发生动态变化，经历复杂且独特的矿化发育阶段。本研究针对小鼠下颌骨中发育中的牙釉质、牙本质与骨骼的力学与化学特性展开探究。我们通过整合显微计算机断层扫描（micro-computed tomography）、纳米压痕（nanoindentation）、能量色散光谱（energy dispersive spectroscopy）以及拉曼光谱（Raman spectroscopy），对出生后发育中的切牙与第一磨牙开展多模态、多尺度分析。本研究揭示了发育中切牙的牙釉质与牙本质的力学、元素组成及化学变化规律。镁、铁与碳磷比与牙釉质特性显著相关，而镁元素组成则与牙本质特性相关。上述结果表明，矿质组成是调控上述发育中颅面硬组织力学特性的关键因素。本整合多模态应用……# 啮齿类牙齿发育的多模态表征
数据集DOI：[10.1021/acsami.5c08408](https://doi.org/10.1021/acsami.5c08408 "DOI链接")

## 数据与文件结构说明
本研究所呈现的数据，源自针对出生后小鼠下颌骨矿化牙组织发育开展的多模态探究。我们结合高分辨率成像（显微计算机断层扫描（micro-computed tomography））、力学测试（纳米压痕（nanoindentation））、元素分析（能量色散X射线光谱（energy dispersive X-ray spectroscopy））与化学表征（拉曼光谱（Raman spectroscopy）），对牙齿发育过程中牙釉质、牙本质与牙槽骨的理化变化进行表征。本研究旨在阐明矿质组成的差异如何影响发育中小鼠牙齿的力学特性变化。

### 文件与变量
#### 文件：F1A.tiff
描述：上颌骨与……的三维显微计算机断层扫描（micro CT）重建图像。