KLF1, KLF2 and c-myc control a regulatory network essential for embryonic erythropoiesis

ChEBI2012-03-12 更新2026-07-21 收录

红细胞生成调控

转录因子网络

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-36427 数据链接链接失效反馈

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KLF1, KLF2 and c-myc control a regulatory network essential for embryonic erythropoiesis

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2012-03-12

Table_1_Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics.DOCX

红细胞生成调控

线粒体动力学

Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of ∼2 × 1011 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) gener

NIAID Data Ecosystem60

Transcriptome analysis of erythroblastic island macrophages. Transcriptome analysis of erythroblastic island macrophages

造血微环境

红细胞生成调控

The erythroblastic island (EBI), composed of a central macrophage and surrounding erythroid cells, was the first hematopoietic niche discovered. The identity of EBI macrophages has thus far remained e

NIAID Data Ecosystem30

Small RNA analysis of human erythropoiesis

红细胞生成调控

microRNA表达谱

Small RNAs including microRNAs play a critical role at different stages of haematopoiesis. The study was designed to profile miRNA expression during human erythropoiesis. Overall design: The CD34+ hae

NIAID Data Ecosystem10

ATAC-seq reveals GATA-1- and heme-dependent chromatin targeting in erythroid cells.

红细胞生成调控

染色质可及性分析

CRISPR/Cas9-mediated ablation of two Alas2 intronic cis-elements in G1E-ER-GATA1 cells strongly reduced GATA-1-induced Alas2 transcription, heme biosynthesis, and GATA-1 regulation of other vital cons

NIAID Data Ecosystem50

Dual threshold optimization and network inference reveal convergent evidence from TF binding locations and TF perturbation responses

转录因子网络

功能位点预测

A high-confidence map of the direct, functional targets of each transcription factor (TF) requires convergent evidence from independent sources. Two significant sources of evidence are TF binding loca

NIAID Data Ecosystem20

KLF1, KLF2 and c-myc control a regulatory network essential for embryonic erythropoiesis

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