Additional file 1 of Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual

Additional file 1: Supplementary Tables. Table S1. Cohort and study visit details (BMDCS). Table S2. Power calculations for heritability analyses. Table S3. Cross-sectional SNP-heritability. Table S4. Ancestry-specific sensitivity analyses. Table S5. Longitudinal SNP-heritability. Table S6. Genetic correlations (baseline). Table S7. Genetic correlations (longitudinal). Table S8. Association results by sex and ancestry. Table S9. Replication in ALSPAC. Table S10. Lookup in UK BioBank GWAS. Table S11. Fracture outcome lookup in PheWEB. Table S12. Topological Associated Domain (TAD) genes. Table S13. DAVID functional annotations for protein-coding TAD genes. Table S14. TAD pathways: GO terms. Table S15. TAD pathways: KEGG terms. Table S16. hMSC-derived osteoblast promoter-focused Capture C loops. Table S17. Pan-tissue eQTLs. Table S18. IL17 Th17 cell promoter-focused Capture C loops. Table S19. hMSC donor line information. Table S20. siRNA details. Table S21. RT-qPCR primers.

补充文件1：补充附表。表S1：队列与研究随访详情（BMDCS）。表S2：遗传力分析的功效计算。表S3：横断面SNP遗传力。表S4：祖先特异性敏感性分析。表S5：纵向SNP遗传力。表S6：遗传相关性（基线阶段）。表S7：遗传相关性（纵向阶段）。表S8：按性别与祖先分层的关联分析结果。表S9：在ALSPAC队列中的验证结果。表S10：英国生物银行全基因组关联研究（UK BioBank GWAS）匹配检索结果。表S11：PheWEB数据库中骨折结局的匹配检索结果。表S12：拓扑关联结构域（Topological Associated Domain, TAD）相关基因。表S13：蛋白编码TAD相关基因的DAVID功能注释。表S14：TAD通路：基因本体（Gene Ontology, GO）术语集。表S15：TAD通路：京都基因与基因组百科全书（Kyoto Encyclopedia of Genes and Genomes, KEGG）术语集。表S16：人骨髓间充质干细胞（human mesenchymal stem cell, hMSC）分化为成骨细胞的启动子聚焦型Capture C互作环。表S17：全组织表达数量性状位点（expression quantitative trait locus, eQTL）。表S18：IL17阳性Th17细胞的启动子聚焦型Capture C互作环。表S19：hMSC供体细胞系信息。表S20：小干扰RNA（small interfering RNA, siRNA）详情。表S21：实时定量聚合酶链反应（reverse transcription quantitative polymerase chain reaction, RT-qPCR）引物序列。