Retinal capillary rarefaction in patients with untreated mild-moderate hypertension

Background: Microvascular rarefaction influences peripheral vascular resistance, perfusion and metabolism by affecting blood pressure and flow pattern. In hypertension microvascular rarefaction has been described in experimental animal studies as well as in capillaroscopy of skin and biopsies of muscle tissue in patients. Retinal circulation mirrors cerebral microcirculation and allows non-invasive investigations. We compared capillary rarefaction of retinal vessels in hypertensive versus normotensive subjects.

Methods: In this study retinal capillary rarefaction in 70 patients with long time (more than 67 month of disease duration) and 64 patients with short time hypertension stage 1 or 2 has been compared to 55 healthy control subjects, who participated in clinical trials in our Clinical Research Center (www.clinicaltrials.gov: NCT01318395, NCT00627952, NCT00152698, NCT01319344). Retinal vascular parameters have been measured non-invasively and in vivo in perfusion image by scannin...

背景：微血管稀疏（microvascular rarefaction）可通过影响血压与血流模式，对外周血管阻力、组织灌注及代谢产生调控作用。现有实验动物研究，以及高血压患者的皮肤毛细血管镜检、肌肉组织活检结果均已证实，高血压患者存在微血管稀疏现象。视网膜循环可反映脑微循环状态，且能够实现无创检测。本研究对比了高血压受试者与血压正常受试者的视网膜血管毛细血管稀疏情况。

方法：本研究纳入70例长期高血压患者（病程超过67个月）、64例短期高血压1期或2期患者，并以55例健康对照受试者作为参照组，所有受试者均参与本临床研究中心开展的临床试验（www.clinicaltrials.gov: NCT01318395, NCT00627952, NCT00152698, NCT01319344）。研究采用无创活体灌注成像技术对视网膜血管参数进行检测，通过扫描...