Rs 1868402 is associated with CSF ptau₁₈₁ levels in individuals with Aβ deposition.

The p-value and the OR for rs1868402 were calculated by comparing the rs1868402 allele frequency in the lowest quartile vs the highest quartile of CSF ptau181 levels, after correction for covariates in the WU-ADRC-CSF (n = 353)+ADNI-CSF (n = 266) samples. CSF Samples from the UW could not be included in this analysis because there is no study analyzing the correlation between the CSF Aβ42 levels and PET-PIB signal in this dataset, and therefore the threshold of CSF Aβ42 levels for PIB positivity is unknown. OR (95%) = Odds ratio with the 95% confidence interval: Odds ratios were calculated comparing the highest vs lowest quartile of CSF ptau181 levels. Samples were stratified based on CSF Aβ42 levels as an approximation of Aβ deposition. For the ADRC samples individuals with Aβ42 levels less than 500 pg/ml were considered positive for Aβ deposition and for ADNI samples the Aβ42 cutoff value of 192 pg/ml was used. Values in boldface indicate significant p-values. ADominant model. Beffects and the standard error of the mean are given in units of standard deviation.