Activity-based protein profiling (ABPP) has emerged as a valuable chemical proteomics method to guide the therapeutic development of covalent drugs by assessing their on-target engagement and off-targ
The metagenome of the gut microbiome encodes tremendous potential for biosynthesizing and transforming small-molecule metabolites through the activities of enzymes expressed by intestinal bacteria. Ac
Protein synthesis and degradation responding to environmental cues is critical for understanding the mechanisms involved. Chemical proteomics introducing bioorthogonal tagging into proteins and isolat
Click-enabled analogues reveal pregnenolone interactomes in cancer and immune cells. TMT-6 experiment of tryptic, carbamidomethylated peptides of mouse CD8+ T-cells after protein pull-down on pregneno
