Supplementary Material for: Passive Monitoring at Home: A Pilot Study in Parkinson Disease

We conducted a pilot study using a passive radio-wave-based home monitor in individuals with Parkinson disease (PD) with a focus on gait, home activity, and time in bed. We enrolled 7 ambulatory individuals to have the device installed in the bedroom of their homes over 8 weeks and performed standard PD assessments at baseline. We evaluated the ability of the device to objectively measure gait and time in bed and to generate novel visualizations of home activity. We captured 353 days of monitoring. Mean gait speed (0.39–0.78 m/s), time in bed per day (4.4–12.1 h), and number (1.4–5.9) and duration (15.0–49.8 min) of nightly awakenings varied substantially across and within individuals. Derived gait speed correlated well with the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale total (r = –0.88, p = 0.009) and motor sub-score (r = –0.95, p = 0.001). Six of the seven participants agreed that their activity was typical and indicated a willingness to continue monitoring. This technology provided promising new insights into the home activities of those with PD and may be broadly applicable to other chronic conditions.

本研究针对帕金森病（Parkinson Disease, PD）患者，采用基于被动无线电波的居家监测设备（passive radio-wave-based home monitor）开展了一项试点研究，重点关注步态、居家活动及卧床时长。本研究招募7名可自主活动的受试者，在其居家卧室部署该设备，监测周期为8周，并于基线阶段完成标准化帕金森病评估。本研究评估了该设备客观测量步态与卧床时长、生成居家活动新型可视化图谱的能力，累计采集353天的监测数据。受试者个体间及个体内的平均步态速度（0.39~0.78 m/s）、每日卧床时长（4.4~12.1 h）、夜间觉醒次数（1.4~5.9次）及单次觉醒时长（15.0~49.8 min）均存在显著差异。推导得到的步态速度与运动障碍学会统一帕金森病评定量表（Movement Disorder Society-Unified Parkinson’s Disease Rating Scale）总分（r=-0.88，p=0.009）及运动分项得分（r=-0.95，p=0.001）呈现良好相关性。7名受试者中有6名认为自身居家活动状态符合日常典型水平，并表示愿意继续接受监测。该技术为帕金森病患者的居家活动研究提供了极具前景的新视角，且有望广泛应用于其他慢性疾病的监测场景。