Crystal structure of sterol 14-alpha demethylase (CYP51) from Leishmania infantum in complex with fluconazole
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Crystal structure of sterol 14-alpha demethylase (CYP51) from Leishmania infantum in complex with fluconazole Descriptor: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Lepesheva, G.I, Hargrove, T.Y, Wawrzak, Z, Waterman, M.R. Deposit date: 2009-12-19 Release date: 2009-12-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14{alpha}-Demethylase (CYP51) from Leishmania infantum. J.Biol.Chem., 286, 2011
婴儿利什曼原虫（Leishmania infantum）甾醇14-α去甲基化酶（sterol 14-alpha demethylase, CYP51）与氟康唑（fluconazole）结合的晶体结构。描述符：2-(2,4-二氟苯基)-1,3-二(1H-1,2,4-三唑-1-基)丙-2-醇、3,6,9,12,15-五氧杂二十三烷-1-醇、含铁原卟啉IX（PROTOPORPHYRIN IX CONTAINING FE）等。作者：Lepesheva G.I.、Hargrove T.Y.、Wawrzak Z.、Waterman M.R.。沉积日期：2009-12-19；发布日期：2009-12-29；最后修改日期：2023-09-06。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.75埃（Å）。引用文献：《婴儿利什曼原虫甾醇14α-去甲基化酶（CYP51）的结构特征决定其底物偏好性与催化参数》，J.Biol.Chem., 286, 2011
创建时间：
2009-12-19
