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A Generator-Produced Gallium-68 Radiopharmaceutical for PET Imaging of Myocardial Perfusion

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https://figshare.com/articles/dataset/_A_Generator_Produced_Gallium_68_Radiopharmaceutical_for_PET_Imaging_of_Myocardial_Perfusion_/1222049
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资源简介:
Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.
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2016-01-15
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