Enrichment of general categories derived from metagene projections of 1,439 yeast expression profiles onto the two-cluster Malawi model.

Additionally, we used the manual and automated (gene set-based) annotations of the yeast samples to determine yeast conditions enriched in Clusters A and B. We observed that the yeast experiments fully cover the “low parasitemia” Cluster A and only a subset – the lower parasitemia region – of the “high parasitemia” Cluster B. Enriched in Cluster B are fermentation (happy growing yeast), perturbation in protein biosynthesis, and knock-outs in yeast peptome dextrose medium. Enriched in Cluster A are stress, starvation, amino acid and nitrogen starvation, respiration, and limiting growth.