The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid

The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid Descriptor: 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ACETATE ION, MANGANESE (II) ION, ... Authors: Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. Deposit date: 2022-05-14 Release date: 2022-12-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023甲型流感H1N1病毒聚合酶来源的PA核酸内切酶（PA endonuclease）N端结构域与3-羟基-4-氧代-1,4-二氢吡啶-2-羧酸形成的复合物 配体描述：3-羟基-4-氧代-1,4-二氢吡啶-2-羧酸、乙酸根离子、锰(II)离子…… 作者：Kohlbrand A.J.、Stokes R.W.、Karges J.、Seo H.、Sankaran B.、Cohen S.M. 提交日期：2022-05-14 发布日期：2022-12-21 最后修改日期：2023-10-25 实验方法：X射线衍射（分辨率2.14埃） 引用文献：《作为流感核酸内切酶抑制剂核心骨架的羟基吡啶酮羧酸电子等排体衍生物》，Acs Med.Chem.Lett., 14, 2023