Moreno2019 - Stochastic model of G1 arrest due to proteostasis decline delimits replicative lifespan in yeast

This model is described within the paper: A G1 arrest due to proteostasis decline delimits replicative lifespan in yeast
David F. Moreno, Kirsten Jenkins, Sandrine Morlot, Gilles Charvin, Attila Csikász-Nagy, Martí Aldea

To be implemented in Copasi.

Missing Event due to difficulties in SBML conversion to run model upon loading model in COPASI, create an event called Budding.

Set the trigger expression to: {Whi5.ParticleNumber} lt 250*({Whi5i.ParticleNumber}+{Whi5.ParticleNumber})/({Whi5.InitialParticleNumber}+{Whi5i.InitialParticleNumber}) AND {Values[Budding]} lt 1.

Uncheck boxes for fire at initial time if true and trigger must remain true.

Leave priority box blank.

Set delay to None.

There are 3 targets:

the value of budding which should be set to one;

the time at budding which should be set to the time;

and the unsynced generation which should be set to generation.