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SAMHD1 is a phospho-regulated Rnase that is essential for restricting HIV-1 infection through direct cleavage of HIV-1 genomic RNA

ChEBI2014-06-13 更新2026-07-21 收录

HIV-1宿主限制因子

病毒基因组RNA切割

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-58418 数据链接链接失效反馈

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SAMHD1 is a phospho-regulated Rnase that is essential for restricting HIV-1 infection through direct cleavage of HIV-1 genomic RNA

应用场景：

创建时间：

2014-06-13

HIV-1宿主限制因子

RNA加工调控

HIV-1 antagonizes SERINC5 via redundant mechanisms, primarily via Nef and additionally via envelope glycoproteins. Paradoxically, the HIV-1 isolates that confer resistance to SERINC5 via envelope also

NIAID Data Ecosystem60

scRNA-seq analysis of human peripheral blood mononuclear cells collected from donors on ART. scRNA-seq analysis of human peripheral blood mononuclear cells collected from donors on ART

HIV-1宿主限制因子

单细胞转录组学

To identify host factors restricting HIV-1 infection, single cell gene expression profiles of immune cells at different timepoints in the course of HIV-1 infection were examined Overall design: Single

NIAID Data Ecosystem50

Engineering T cells to encode natural post-integration barriers to HIV-1 replication. Engineering T cells to encode natural post-integration barriers to HIV-1 replication

HIV-1宿主限制因子

T细胞治疗

HIV-1 virion production is inefficient in cells derived from mice and other rodents. Inefficient production maps, in part, to a species-specific polymorphism in the cellular gene, CCNT1. In human cell

NIAID Data Ecosystem40

Cryo-EM structure of the HIV-1 restriction factor human SERINC3

蛋白质结构解析

HIV-1宿主限制因子

Cryo-EM structure of the HIV-1 restriction factor human SERINC3 Descriptor: Serine incorporator 3, SiA Authors: Purdy, M.D, Leonhardt, S.A, Yeager, M. Deposit date: 2021-08-16 Release date: 2022-08-24

Protein Data Bank Japan2023-09-06 更新50

Gene Expression Analysis of a Panel of Cell Lines That Differentially Restrict HIV-1 CA Mutants Infection in a Cyclophilin A-Dependent Manner

HIV-1宿主限制因子

基因表达谱比较分析

HIV-1 replication is dependent on binding of the viral capsid to the host protein cyclophilin A (CypA). Interference with cyclophilin A binding, either by mutations in the HIV-1 capsid protein (CA) or

NIAID Data Ecosystem40

SAMHD1 is a phospho-regulated Rnase that is essential for restricting HIV-1 infection through direct cleavage of HIV-1 genomic RNA

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