Determining The Suitability Of C2C12 And Hek293 In Dual Luciferase Assay (Dla) For Acvr1 (Alk2) And Tgfbr1 (Alk5)

Aside from having high potency towards ACVR1/ALK2, inhibitor compounds ideally should be highly selective and not target other members of the Transforming Growth Factor beta (TGFb) superfamily. TGFBR1/ALK5 is selected for off-target screening because of its potential role in cardiac functions.除了对激活素受体1/激活素受体样激酶2（ACVR1/ALK2）具有高效活性外，理想的抑制剂化合物应具备高度选择性，且不得靶向转化生长因子β（Transforming Growth Factor beta, TGFb）超家族的其他成员。转化生长因子β受体1/激活素受体样激酶5（TGFBR1/ALK5）因其在心脏功能中潜在的作用，被选作脱靶筛选的靶标。