Composite clinical outcome score.^*

*The score was devised pre hoc by consensus opinion among the investigators. We assigned greatest significance to weight gain, due to its leading clinical importance in response to TB treatment [57]–[61], and its reliable objectivity. The selected cut-off of weight gain <5% was guided by previously-published results [57]. The lung function cut-offs were guided by knowledge of test repeatability (accuracy) and plausible improvements in FEV1 during the given time frame [38].