Divergent Synthesis of Functionalized Carbocycles through Organosilane-Directed Asymmetric Alkyne–Alkene Reductive Coupling and Annulation Sequence
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An organosilane-directed alkyne–alkene reductive coupling of readily available propargylsilanes is used to access densely functionalized chiral allylsilanes. The divergent reactivity of the allylsilanes can be controlled to afford a range of novel carbocyclic ring systems through an intramolecular allylation, [3+2] annulation, and Sakurai-like homodimerization.
创建时间:
2016-02-20



