Lipid profiles and obesity as potential risk factors of sudden sensorineural hearing loss

Objectives: The objective of our study was to establish whether increased lipid profiles and obesity affect the prevalence and prognosis of sudden sensorineural hearing loss (SSNHL). Methods: This was a case-controlled study with a longitudinal design. According to our criteria, 324 patients with SSNHL were included in this study. To manage potential covariates, 972 subjects with normal hearing from the Korean National Health and Nutrition Examination Survey were matched as control group according to their propensity scores. Age, level of total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and body mass index (BMI) were obtained from the clinical data. Multivariate logistic regression analysis was used to investigate the association between SSNHL and lipid profiles or obesity in the 1296 subjects. Multivariate Cox regression analysis was used to determine whether lipid profiles and obesity are prognostic ...

研究目的：本研究旨在明确血脂谱升高与肥胖是否会影响突发性感音神经性听力损失（sudden sensorineural hearing loss，SSNHL）的患病率与预后。研究方法：本研究为一项采用纵向设计的病例对照研究。按照本研究纳入标准，共纳入324例SSNHL患者。为控制潜在混杂变量，本研究从韩国国民健康与营养检查调查（Korean National Health and Nutrition Examination Survey）中选取972名听力正常者作为对照组，并通过倾向得分进行匹配。从临床资料中提取受试者的年龄、总胆固醇（total cholesterol, TC）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol, HDL-C）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol, LDL-C）、甘油三酯（triglycerides, TG）以及体质量指数（body mass index, BMI）水平。针对1296名受试者，采用多因素logistic回归分析探究SSNHL与血脂谱或肥胖之间的关联。采用多因素Cox回归分析明确血脂谱与肥胖是否为SSNHL的预后影响因素……