The FK1 domain of FKBP51 in complex with SAFit-analog 23b
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The FK1 domain of FKBP51 in complex with SAFit-analog 23b Descriptor: (1-ethylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Meyners, C, Buffa, V, Hausch, F. Deposit date: 2024-03-27 Release date: 2024-06-12 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
FKBP51的FK1结构域与SAFit类似物23b形成的复合物 描述符：(1-乙基吡唑-4-基)甲基 (2S)-1-[(2S)-2-环己基-2-(3,4,5-三甲氧基苯基)乙酰基]哌啶-2-羧酸酯、肽基脯氨酰顺反异构酶FKBP5 作者：Meyners, C、Buffa, V、Hausch, F 存档日期：2024-03-27 发布日期：2024-06-12 最后修改日期：2024-09-11 实验方法：X射线衍射（分辨率2.4 Å） 引用文献：《含1,4-吡唑基的SAFit类似物为配体效率与类药特性更优的选择性FKBP51抑制剂》，发表于《ChemMedChem》，2024年，第19卷
