Palladium and Copper Cocatalyzed Tandem N–H/C–H Bond Functionalization: Synthesis of CF3-Containing Indolo- and Pyrrolo[2,1-a]isoquinolines

A palladium- and copper-catalyzed tandem N–H/C–H bond functionalization reaction of ortho-(2-chlorovinyl)­bromobenzenes with indoles and pyrroles has been developed. A variety of CF3-containing indolo- and pyrrolo­[2,1-a]­isoquinolines were prepared in moderate to good yields via the cyclization of 1-bromo-2-(2-chloro-3,3,3-trifluoroprop-1-enyl)­benzenes with indoles and pyrroles.