Epigenome-wide association study of diabetic chronic kidney disease progression

Since the etiology of diabetic chronic kidney disease (CKD) is multifactorial, studies on DNA methylation for kidney function deterioration have rarely been performed despite the need for an epigenetic approach. Therefore, this study aimed to identify epigenetic markers associated with CKD progression based on the decline in the estimated glomerular filtration rate in diabetic CKD in Korea. We profiled genome-wide DNA methylation using Infinium MethylationEPIC array using whole blood samples from 180 CKD patients