Synthesis of 2,5-Bis(spirocyclohexane)-Substituted Nitroxides of Pyrroline and Pyrrolidine Series, Including Thiol-Specific Spin Label: An Analogue of MTSSL with Long Relaxation Time
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资源简介：
The nitroxides of 7-azadispiro[5.1.5.2]pentadecane and
7-azadispiro[5.1.5.2]pentadeca-14-ene
series have been prepared, including thiol-specific methane thiosulfonate
spin label for site-directed spin labeling. The effect of spirocyclohexane
moieties on chemical and spectral properties has been studied. The
obtained temperature dependencies of electron spin relaxation parameters
demonstrate that new nitroxides may be suitable for PELDOR distance
measurements at 80–120 K. Moreover, the new nitroxides demonstrated
much higher stability toward reduction by ascorbate than spirocyclohexane-substituted
nitroxides of piperidine series and showed 1.3–3.14 times lower
reduction rates compared to corresponding 2,2,5,5-tetramethyl nitroxides.
创建时间：
2016-02-20
