Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-benzyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol

Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-benzyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[3-(1-benzyl-1H-1,2,3-triazol-4-yl)propyl]sulfanyl}methyl)pyrrolidin-3-ol, 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ... Authors: Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. Deposit date: 2018-07-02 Release date: 2019-03-20 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62, 2019

本数据集包含幽门螺杆菌（Helicobacter pylori）5'-甲硫基腺苷/S-腺苷同型半胱氨酸核苷酶（MTAN）与(3R,4S)-1-[(4-氨基-5H-吡咯并[3,2-d]嘧啶-7-基)甲基]-4-[[[3-(1-苄基-1H-1,2,3-三唑-4-基)丙基]硫代]甲基]吡咯烷-3-醇形成复合物的晶体结构。
描述项：(3R,4S)-1-[(4-氨基-5H-吡咯并[3,2-d]嘧啶-7-基)甲基]-4-[[[3-(1-苄基-1H-1,2,3-三唑-4-基)丙基]硫代]甲基]吡咯烷-3-醇、1,2-乙二醇、5'-甲硫基腺苷/S-腺苷同型半胱氨酸核苷酶……
作者：Harijan, R.K、Ducati, R.G、Bonanno, J.B、Almo, S.C、Schramm, V.L
入库日期：2018-07-02
发布日期：2019-03-20
最后修改日期：2023-10-11
实验方法：X射线衍射（分辨率1.45 Å）
引用文献：《幽门螺杆菌甲硫基腺苷核苷酶与人甲硫基腺苷磷酸化酶的选择性抑制剂》，《药物化学杂志》（J. Med. Chem.），第62卷，2019年