Summary of the 24 highly cited studies with replications.

Table shows the references for both studies, the general PICO components, the original study’s conclusion, the outcome measure and the effect sizes (with CIs) found in the original study and replication. Replication studies for PARTNER A [35] and NEJSG [32] were obtained from 2-study meta-analyses found in our search [36, 37] and their effect sizes are drawn from these meta-analyses; in the case of IPASS [31], this corresponds to a subgroup matching that of the highly cited study. Two pairs of studies [MR CLEAN [63] and ESCAPE, Cheng et al. 2009 [33] and SHARP [56]] are replicated by the same meta-analyses [Rodrigues et al. 2016 [43] and Niu et al. 2016 [42]].