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Organocatalytic Cascade Reactions Based on Push−Pull Dienamine Platform: Synthesis of Highly Substituted Anilines

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NIAID Data Ecosystem2026-03-06 收录
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A practical and novel one-pot organocatalytic selective process for the cascade synthesis of highly substituted o-hydroxydiarylamines and o-pyrrolidin-1-yldiarylamines is reported. Direct combination of amine-catalyzed cascade Knoevenagel/Michael/aldol condensation/decarboxylation and cascade enamine amination/isoaromatization of alkyl acetoacetates, aldehydes, and nitrosoarenes furnished the highly functionalized anilines with high yields.

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2016-02-29
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