Commenting round on the draft corrected Test Guideline 456 on the H295R Steroidogenesis Assay
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In 2022, Test Guideline 456: H295R Steroidogenesis Assay was revised and a new data interpretation procedure (DIP) adopted. This new DIP introduced a new (additional) criteria to conclude to a positive result (induction or inhibition), i.e. result > 1.5-fold induction or inhibition threshold from the solvent control. It recently appeared that this...
