Multisubcellular organelle-targeting nanoparticle for synergistic chemotherapy and photodynamic/photothermal tumor therapy - supplementary data

Background: The subcellular organelle-targeting strategy has attracted wide attention for a variety
of reasons, including strong specificity, high accuracy, low dose administration and few side effects.
It is an important and challenging task to explore the multisubcellular organelle-targeting strategy
to achieve effective tumor treatment. Materials & methods: Using bovine serum albumin as a
nanoreactor, BSA/Cu/NQ/IR780/DOX nanoparticles (NPs) were constructed via drug-induced protein
self-assembly. Folic acid was then coupled to the surface of NPs to prepare folate receptortargeted
FA-BSA/Cu/NQ/IR780/DOX NPs. Results & conclusion: The FA-BSA/Cu/NQ/IR780/DOX NPs
exhibit multifunctional properties, including multisubcellular organelle-targeting, induction of response
release in the tumor microenvironment, fluorescence imaging capabilities and potential for synergistic
chemotherapy and photodynamic/photothermal tumor therapy.