Palladium-Catalyzed Asymmetric [3 + 2] Cycloaddition of 5‑Vinyloxazolidinones with Imines Using Chiral Ammonium-Phosphine Hybrid Ligand

A palladium-catalyzed asymmetric [3 + 2] annulation reaction between racemic 5-vinyloxazolidinones and N-sulfonyl imines was established. Under the influence of the palladium complex with a chiral ammonium-phosphine hybrid ligand, the cycloaddition proceeded smoothly to yield imidazolidines bearing α-amino quaternary stereocenters in high yields with excellent diastereo- and enantioselectivities.