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CRISPR / CAS-adenine deaminase based compositions, systems and methods for targeted nucleic acid editing

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国家林业和草原科学数据中心2023-02-12 更新2024-03-07 收录
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The present invention provides systems, methods and compositions for targeting and editing nucleic acids. In particular, the present invention provides an unnaturally derived or engineered RNA-targeting system comprising an RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or a catalytic domain thereof. The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof. The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.
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国家林业和草原科学数据中心
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2023-02-12
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