EPZ-6438/GRag combination increases EPZ-6438 sensitivity in EZH2 Y646 mutant cell lines and overcomes insensitivity in cell lines resistant to EZH2 inhibition.
收藏Figshare2015-12-02 更新2026-04-29 收录
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https://figshare.com/articles/dataset/_EPZ_6438_GRag_combination_increases_EPZ_6438_sensitivity_in_EZH2_Y646_mutant_cell_lines_and_overcomes_insensitivity_in_cell_lines_resistant_to_EZH2_inhibition_/1266586
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Values in the table represent EPZ-6438 mean IC50 values ± SEM (at least n = 2) for the indicated time points and dosing schedules. EPZ-6438 IC50 values were not extrapolated beyond the highest and lowest doses of EPZ-6438 (1 µM, and 0.004 µM, respectively). In cases where IC50 values could not be averaged due to non-extrapolated values, all replicates are listed. GRag: glucocorticoid receptor agonist, Pred: Prednisolone.EPZ-6438/GRag combination increases EPZ-6438 sensitivity in EZH2 Y646 mutant cell lines and overcomes insensitivity in cell lines resistant to EZH2 inhibition.
创建时间：
2015-12-02
