Microbiome and metabolome features of patients with diarrhea-type irritable bowel syndrome complicated with anxious-depressive states

Patients with diarrhea-type irritable bowel syndrome (IBS-D) often have symptoms of anxiety and depression. Several studies suggest that IBS-D patients may suffer from structural disturbances in the gut flora associated with psychiatric symptoms such as anxiety and depression. It has also been found in clinic that some IBS-D patients can benefit from certain probiotic treatments. In this study, 16SrDNA sequencing and non-targeted metabolomics analysis were used to explore the differential microorganisms and metabolites related to the physical and psychological symptoms of IBS-D patients, which provided clues for intestinal targeted therapy in IBS-D patients.