Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics

Ther are raw sequencing samples. The name of each file describes itself. For example, "Tetracycline_lineage1_day3.fastq" means lineage 1 of E. coli K12 evolved against tetracycline from day 3. These sequences can be mapped to the reference genome (E. coli BW25113 strain K-12 chromosome; GCF_000750555.1). We have sequenced our lab E. coli BW25113 strain presented as WT.fastq.本数据集包含原始测序样本。各文件名自带说明信息。例如，"Tetracycline_lineage1_day3.fastq"代表第3天采集的、经四环素胁迫进化的大肠杆菌（E. coli）K12品系第1个谱系的测序数据，该文件采用FASTQ格式（FASTQ）。上述测序序列可比对至参考基因组：大肠杆菌（E. coli）BW25113菌株K-12染色体，对应编号为GCF_000750555.1。本研究已对实验室保存的大肠杆菌（E. coli）BW25113菌株进行测序，对应文件为WT.fastq。