GPR68 is an essential flow sensor in arteriolar endothelium, and is a critical signaling component in cardiovascular pathophysiology RNAseq of cells from mesenteric endothelium of mice plus and minus
Cells were pre-incubated for 20 min with the ecto-nucleotidase inhibitor APCP (5′-(alpha,beta-methylene) diphosphate) at a concentration of 10−6 M. Ca2+ transients were analyzed, and the ratio after s
Csk (C-terminal Src kinase), a protein-tyrosine kinase, bearing the Src homology 2 and 3 (SH2 and SH3) domains, has been implicated in phosphorylation of c-Src Tyr-527, resulting in suppression of c-S