We used RNA-seq to investigate transcriptional changes in human islet grafts that were treated in vivo with tacrolimus or sirolimus. We show that this treatment induces broad transcriptional dysregula
Mismatches between mature recipient and donor HLA proteins can trigger alloreactivity upon transplantation. Recent studies suggest that also the leader peptide of HLA class I alleles may affect the tr
Transcriptome analysis of murine T cells pre- and post-transplant. Overall design: Sorted CD4 and CD8 splenic T cells where evaluated by RNA-seq either at the time of allogeneic transplant or 14 days
HLA Class II Haplotype Frequency Distributions (for 99% haplotypes per population) and HLA Class II Simulated Populations (Genotype level information for sample sizes of 1000, 5000, 10000 simulated in